THE PSL

”Parallel Synthesis Laboratory"

Novel, homochiral synthons co-located with our PSL for rapid hit follow-up and lead optimization.

PARTNERING WITH LCC FOR VIRTUAL SCREENING PROJECTS

Access high quality lead-like chemical space through our virtual library, paired with a team of experts working in our Parallel Synthesis Laboratory in UK.

VL enumerated based on our proprietary fragments which are co-located with the PSL.
Find your virtual hit which can be rapidly accessed in the PSL, through synthetically validated transformations between LCC's fragment and commercially available building blocks.
In-house computational expertise, as well as partnerships with external experts within computational chemistry and medicinal chemistry design.
Accomplished Scientific Advisory Board.

HIT EXPLORATION AND LEAD OPTIMISATION WITH NEAR-NEIGHBOUR ANALOGUE ACCESS

Expert team onsite for supporting client projects and working collaboratively on the design / selection / prioritisation of the nearest neighbour analogues for rapid and effective SAR exploration.
Access matched molecular pairs and covalent fragment collections.

SERVICE AND PRODUCT PROVIDER

We operate under both a FFS and FTE model, giving you the option of using our expert chemists and intelligently designed chemical space to explore and optimize your hits.

Examples of potential projects:

A client screens our fragment library, get some hits, and uses our lead-like virtual library as a way of selecting lead-like molecules which are based on the fragment hits.

A client screens our virtual library, gets hits, and we synthesise them in our parallel synthesis laboratory.

A client has independently identified a lead series based on molecules with e.g. a chiral piperidine core. The client then selects near-neighbour analogues based on LCC’s collection of chiral piperidine scaffolds/fragments from which to design and synthesize lead-like analogues around the hit series.