THE PSL

”Parallel Synthesis Laboratory"

 

Novel, homochiral synthons co-located with our PSL for rapid hit follow-up and lead optimization.

PARTNERING WITH LCC FOR VIRTUAL SCREENING PROJECTS

Access high quality lead-like chemical space through our virtual library, paired with a team of experts working in our Parallel Synthesis Laboratory in UK.




  
  • VL enumerated based on our proprietary fragments which are co-located with the PSL.
  • Find your virtual hit which can be rapidly accessed in the PSL, through synthetically validated transformations between LCC's fragment and commercially available building blocks.
  • In-house computational expertise, as well as partnerships with external experts within computational chemistry and medicinal chemistry design.
  • Accomplished Scientific Advisory Board.

 

HIT EXPLORATION AND LEAD OPTIMISATION WITH NEAR-NEIGHBOUR ANALOGUE ACCESS

  
  • Expert team onsite for supporting client projects and working collaboratively on the design / selection / prioritisation of the nearest neighbour analogues for rapid and effective SAR exploration.
  • Access matched molecular pairs and covalent fragment collections.

 

 

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SERVICE AND PRODUCT PROVIDER

We operate under both a FFS and FTE model, giving you the option of using our expert chemists and intelligently designed chemical space to explore and optimize your hits.

 

Examples of potential projects:

  1. A client screens our fragment library, get some hits, and uses our lead-like virtual library as a way of selecting lead-like molecules which are based on the fragment hits.

  2. A client screens our virtual library, gets hits, and we synthesise them in our parallel synthesis laboratory.

  3. A client has independently identified a lead series based on molecules with e.g. a chiral piperidine core. The client then selects near-neighbour analogues based on LCC’s collection of chiral piperidine scaffolds/fragments from which to design and synthesize lead-like analogues around the hit series.

FACILITIES

MEET THE TEAM

Mark Jones

Head of PSL

Ross Goodyear

Deputy Team Leader

Joshua Bell

Associate Chemist

MEET THE REST OF THE TEAM

Parallel Synthesis Laboratory