USE LCC’S BIFUNCTIONAL LINKERS TO CONTROL THE STRUCTURAL ORIENTATION OF YOUR PROTACS.

While efforts are focusing on the protein of interest ligand, and the E3 ubiquitin ligase recruiting ligand, LCC’s compounds present an original alternative to classical linkers and novel options in terms of overall structure/activity of the PROTACs.

We have designed a set of Bifunctional linkers based on three key design principles: 

  • Low number of rotatable bonds, which gives higher conformational control and improves cell permeability.
  • Avoid hydrogen bonds donors to improve cell permeability, whilst reducing interference with the binding of the ligands.
  • Varied linker length with rigid core scaffolds.

Linkers for PROTACS


ACCESS 3D-RICH BIFUNCTIONAL LINKERS

  • Systematic changes in conformation via exit vectors distribution.
  • Selected exit vectors for ligand coupling.
  • Good variety of chain lengths.
  • No additional HBD ’s.
  • Reduced number of rotatable bonds.
  • Racemic and chirally-pure material available.

PROTACS CHEMISTRY PORTAL

To assist you in your research effort and tackle a more collaborative and intense approach, we have developed a full-service called the Chemistry Portal.

The portal will help you increase speed, gain time, streamline chemistry processes and reduce costs.