We have designed and synthesized a proprietary set of unique linkers to enable rapid synthesis of novel bi-functional molecules with improved drug-like properties. These newly designed set of linkers are an alternative to classical PEG-like linkers, offering a more rigid structure to reduce the entropic penalty when achieving the correct locked conformation.
Our semi-flexible linkers are designed to modulate the physicochemical properties of bi-functional molecules through focusing on four key design parameters: