USE LCC’S HETEROBIFUNCTIONAL LINKERS TO CONTROL THE STRUCTURAL ORIENTATION OF YOUR CHEMISTRY.

We have designed and synthesized a proprietary set of unique linkers to enable rapid synthesis of novel bi-functional molecules with improved drug-like properties. These newly designed set of linkers are an alternative to classical PEG-like linkers, offering a more rigid structure to reduce the entropic penalty when achieving the correct locked conformation.

Our semi-flexible linkers are designed to modulate the physicochemical properties of bi-functional molecules through focusing on four key design parameters:

• Low number of rotatable bonds, which gives higher conformational control and improves cell permeability.
• Avoid hydrogen bond donors to improve cell permeability, whilst reducing interference with the binding of the ligands.
• Varied linker length with rigid core scaffolds.
• Different combinations of terminal synthetic handles.