USE LCC’S SEMI-FLEXIBLE LINKERS TO CONTROL THE STRUCTURAL ORIENTATION OF YOUR PROTACS.

While efforts are focusing on the protein of interest ligand, and the E3 ubiquitin ligase recruiting ligand, LCC’s compounds present an original alternative to classical linkers and novel options in terms of overall structure/activity of the PROTACs.

We provide semi-flexible linkers that won’t participate into the binding (no supplementary HBD). With a better control of the structural arrangement, new opportunities arise.

Representative examples of our types of linker

Linkers for PROTACS


ACCESS 3D-SHAPED SEMI-FLEXIBLE LINKERS

  • Systematic changes in conformation via exit vectors distribution.
  • Selected exit vectors for ligand coupling.
  • Good variety of chain lengths.
  • No additional HBD ’s.
  • Reduce number of rotatable bonds.
  • Racemic and chirally-pure material available.

PROTACS CHEMISTRY PORTAL

To assist you in your research effort and tackle a more collaborative and intense approach, we have developed a full-service called the Chemistry Portal.

The portal will help you increase speed, gain time, streamline chemistry processes and reduce costs.