USE LCC’S HETERO BIFUNCTIONAL LINKERS TO CONTROL THE STRUCTURAL ORIENTATION OF YOUR CHEMISTRY.

We have designed and synthesized a proprietary set of unique linkers to enable rapid synthesis of novel bi-functional molecules with improved drug-like properties. These newly designed set of linkers are an alternative to classical PEG-like linkers, offering a more rigid structure to reduce the entropic penalty when achieving the correct locked conformation.

Our semi-flexible linkers are designed to modulate the physicochemical properties of bi-functional molecules through focusing on four key design parameters:

  • Low number of rotatable bonds, which gives higher conformational control and improves cell permeability.
  • Avoid hydrogen bond donors to improve cell permeability, whilst reducing interference with the binding of the ligands.
  • Varied linker length with rigid core scaffolds.
  • Different combinations of terminal synthetic handles.

Linkers for PROTACS


ACCESS 3D-RICH HETERO BIFUNCTIONAL LINKERS

  • Systematic changes in conformation via exit vectors distribution.
  • Selected exit vectors for ligand coupling.
  • Good variety of chain lengths.
  • No additional HBD ’s.
  • Reduced number of rotatable bonds.
  • Racemic and chirally-pure material available.

LINKER CHEMISTRY PORTAL

To assist you in your research effort and tackle a more collaborative and intense approach, we have developed a full-service called the Chemistry Portal.

The portal will help you increase speed, gain time, streamline chemistry processes and reduce costs.