3D-RICH

FRAGMENTS

 

Enhance your fragment library with LCC's novel, diverse, 3D-rich fragments

EXPLORE NEW CHEMICAL SPACE WITH ACCESS TO 3D-RICH, COVALENT, AND ENANTIOPAIR FRAGMENTS

FRAGMENT PROPERTY ANALYSIS - KEY FEATURES

  • Ro3 compliant
  • Good distribution for logP, logD, and PSA, predicting good solubilities, and membrane permeability
  • Low number of rotatable bonds
  • Library extends into novel fragment space, which can complement existing 'flatland' published libraries
 

PRE-PLATED SETS OF ENANTIOPAIR FRAGMENTS

  • 3D scaffolds made on gram scale ready for immediate follow-up and hit expansion.
  • Onsite Parallel Synthesis Lab for expedited synthesis of virtual hits.
  • Nearest neighbour analogues rapidly accessible.

 

 

SHOWCASING LCC’S PRE-PLATED FRAGMENT LIBRARIES FOR COMMERCIAL APPLICATION

  • Pre-plated libraries (96 well-plates) which sample a diverse range of chemical space to be made commercially available for screening.
  • Enantiopairs which can be used as enantioprobes in chemoproteomics (as described by Cravatt et al.)
  • Little overlap with other commercially available libraries, LCC is populating underexplored chemical space.

How can we help YOU?

If you would like to discuss your fragment specification requirements further, please get in touch with our Technical Support Team.

 

Chiral Fragments Library - LCC