3D-RICH

FRAGMENTS

 

Enhance your fragment library with LCC's novel, homochiral, enantiopair fragments

EXPLORE NEW CHEMICAL SPACE WITH ACCESS TO 3D-RICH, COVALENT, AND ENANTIOPAIR FRAGMENTS

FRAGMENT PROPERTY ANALYSIS - KEY FEATURES

Parameters and count
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Fragment Property Analysis

SOLUBILITY

Good aqueous solubility is >1000 µM, acceptable aqueous solubility is >500 µM.

Solubility

Kinetic aqueous solubility data was measured by XenoGesis for 100 fragments from LCC’s catalogue:

  • 92% are soluble at 100mM in DMSO
  • 8% were not soluble at 100mM in DMSO, 10mM solution prepared.

Kinetic solubility was determined in PBS buffer (pH 7.4) containing 1% DMSO:

  • 87% were found to possess kinetic solubility >1000 μM.
  • 99% > 500 μM.

FRAGMENT LIBRARIES

  • 3D synthons made on gram scale ready for immediate follow-up and hit expansion.
  • Onsite Parallel Synthesis Lab for expedited synthesis of virtual hits.
  • Nearest neighbour analogues rapidly accessible.

 

 

Pre-Plated Fragment

SHOWCASING LCC’S PRE-PLATED FRAGMENT LIBRARIES FOR COMMERCIAL APPLICATION

  • Pre-plated libraries (96 well-plates) which sample a diverse range of chemical space to be made commercially available for screening.
  • Enantiopairs which can be used as enantioprobes in chemoproteomics (as described by Cravatt et al.)
  • Little overlap with other commercially available libraries, LCC is populating underexplored chemical space.

HIT-IDENTIFICATION TO LEAD OPTIMISATION WITH LCC’S FRAGMENTS AND VIRTUAL LIBRARY

Hit-identification Strategies

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How can we help YOU?

If you would like to discuss your fragment specification requirements further, please get in touch with our Technical Support Team.

 

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Chiral Fragments Library - LCC