3D-RICH

FRAGMENTS

 

Enhance your fragment library with LCC's novel, homochiral, enantiopair fragments

EXPLORE NEW CHEMICAL SPACE WITH ACCESS TO 3D-RICH, COVALENT, AND ENANTIOPAIR FRAGMENTS

FRAGMENT PROPERTY ANALYSIS - KEY FEATURES

SOLUBILITY

Good aqueous solubility is >1000 µM, acceptable aqueous solubility is >500 µM.

Solubility

Kinetic aqueous solubility data was measured by XenoGesis for 100 fragments from LCC’s catalogue:

  • 92% are soluble at 100mM in DMSO
  • 8% were not soluble at 100mM in DMSO, 10mM solution prepared.

Kinetic solubility was determined in PBS buffer (pH 7.4) containing 1% DMSO:

  • 87% were found to possess kinetic solubility >1000 μM.
  • 99% > 500 μM.

FRAGMENT LIBRARIES

  • 3D synthons made on gram scale ready for immediate follow-up and hit expansion.
  • Onsite Parallel Synthesis Lab for expedited synthesis of virtual hits.
  • Nearest neighbour analogues rapidly accessible.

 

 

Pre-Plated Fragment

SHOWCASING LCC’S PRE-PLATED FRAGMENT LIBRARIES FOR COMMERCIAL APPLICATION

  • Pre-plated libraries (96 well-plates) which sample a diverse range of chemical space to be made commercially available for screening.
  • Enantiopairs which can be used as enantioprobes in chemoproteomics (as described by Cravatt et al.)
  • Little overlap with other commercially available libraries, LCC is populating underexplored chemical space.

HIT-IDENTIFICATION TO LEAD OPTIMISATION WITH LCC’S FRAGMENTS AND VIRTUAL LIBRARY

Hit-identification Strategies

How can we help YOU?

If you would like to discuss your fragment specification requirements further, please get in touch with our Technical Support Team.

 

GET IN TOUCH

Chiral Fragments Library - LCC