Hit Identification to Lead Optimisation

Discover how LCC’s highly developable chemical space has been intelligently designed to support projects from hit identification, to hit expansion and lead optimisation.

HIT-ID STRATEGIES

Use the Parallel Synthesis Team's expertise to explore near neighbour analogues...

LEAD OPTIMISATION WITH NEAR NEIGHBOUR-ANALOGUES

LCC's Parallel Synthesis lab is conveniently located with the stock, meaning rapid and effective SAR exploration is easily accessible for the expert team onsite to support client projects.

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Progress from Ro3 fragment hits through Ro4, high-quality lead-like chemical space using our virtual library, which has been enumerated based on our proprietary fragment library.

LEAD EXPANSION WITH LCC'S 3DISCOVERY^TM VIRTUAL LIBRARY

After identifying fragment hits using the in-stock fragment library, our intelligently designed virtual library is an ideal tool for efficient hit expansion.

Parallel Synthesis Laboratory co-located with the in-stock fragment collection, giving rapid synthesis of lead-like molecules

Validated transformations have been used to design the poised library, meaning there is a higher synthetic success rate in converting virtual hits to lead-like molecules.

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