Hit Identification to Lead Optimisation

 

Discover how LCC’s highly developable chemical space has been intelligently designed to support projects from hit identification, to hit expansion and lead optimisation.

HIT-ID STRATEGIES

 

Use the Parallel Synthesis Team's expertise to explore near neighbour analogues...

LEAD OPTIMISATION WITH NEAR NEIGHBOUR-ANALOGUES

LCC's Parallel Synthesis lab is conveniently located with the stock, meaning rapid and effective SAR exploration is easily accessible for the expert team onsite to support client projects.

   

 

 

 

Progress from Ro3 fragment hits through Ro4, high-quality lead-like chemical space using our virtual library, which has been enumerated based on our proprietary fragment library.

LEAD EXPANSION WITH LCC'S 3DISCOVERYTM VIRTUAL LIBRARY

  1. After identifying fragment hits using the in-stock fragment library, our intelligently designed virtual library is an ideal tool for efficient hit expansion.

  2. Parallel Synthesis Laboratory co-located with the in-stock fragment collection, giving rapid synthesis of lead-like molecules

  3. Validated transformations have been used to design the poised library, meaning there is a higher synthetic success rate in converting virtual hits to lead-like molecules.

Hit Identification to Lead Optimisation