of the
Follow our MOtM once a month to see new compounds, recent examples of their applications,
potential breakthroughs, and much more.
LCC have identified an area to support emerging technologies, with the current expanding research into PROTACs and their movement into clinical trials. Our newly designed set of PROTACs linkers are an alternative to…
Photocatalysis has seen a lot of attention over the past decade which has led to the development of
new methodologies and technologies for the synthetic organic chemist. A range of powerful
transformations.…
A recent publication from the Cravatt group is highlighting the importance of enantiomeric probe pairs (also called “enantiopairs”) in the context of small-molecule interactions with proteins in human cells. Numerous stereochemistry-dependent protein-fragment interactions were…
As discussed in our Nov.2020 Molecules of the Month, starting from LCC’s proprietary 3D-rich fragments and working with one of the leaders in the cheminformatics field, the fragments have….
In order to allow researchers to take full advantage of recently published work in the field of DEL (in terms of on-DNA reactions’ development), LCC designed a novel collection of 3D-rich.…
The benefits of rapid access to nearest neighbour analogues during SAR are already well accepted. In order to support this important stage of a project, and accelerate discoveries, LCC took advantage of its.…
In order to create a Ro4 lead like virtual library that is drug like novel diverse 3D-rich and enantiomerically pure LCC collaborated with one of the best in class cheminformatics companies (This set of > 5,000,000.…
In order to reduce the lack of available trifunctional scaffolds for DEL on the market and therefore accelerate the synthetic effort of new libraries, LCC’s team.…
To maximise the power of DEL screening, it is important to expand the structural diversity of the screening libraries. To do so, researches must (a) focus on developing new DNA compatible reactions, and (b) introduce novel DEL scaffolds with suitable.…
LCC’s fragment collection contains a high proportion of secondary amines that are ideally suited to be converted into covalent fragments. We’ve selected 958 of our compact, cyclic-based, stereo-defined...
