of the
Follow our MOtM once a month to see new compounds, recent examples of their applications,
potential breakthroughs, and much more.
LCC’s October MotM showcases the work done in collaboration with Anagenex to validate a representative set of LCC’s DEL Synthons for on-DNA synthesis. Download the pdf below for more details!
Fragment-based drug discovery (FBLD) has proven to be an increasingly important tool for discovering lead compounds, through using both biochemical and biophysical methods to detect very small molecules. Thanks to the success of FBLD…
Our September edition of Molecules of the Month is focused on an excellent paper published this week by Tao et al., titled ‘Targeted Protein Degradation by Electrophilic PROTACs that Stereo selectively and Site-Specifically Engage DCAF1’.1 …
In keeping with our aim to continue looking for new ways in which we can play a part in the discovery of drugs, LCC are excited to announce that our first focused VL is ready to be screened! We have chosen to base this library on…
LCC are pleased to announce that the latest version of our Virtual Library is ready to be screened! This space is still Ro4, lead-like, novel, diverse and 3D-rich but has been expanded to >2.8M compounds. We have also made the decision to base the VL on…
There is a lack of representation of commercially available sp3-rich molecules. At LCC, we have invested heavily into absolute stereochemical determination and quantification of enantiomeric excess measurements, meaning we are in a great position to provide …
Constrained γ-amino acids are increasingly employed in drug discovery programmes because of
their desirable properties and lack of representation in the commercial space. LCC has developed synthetic photocatalysis methodologies, to provide access to…
It is important to think outside of the box when trying to innovate within drug discovery – are there ways in which we can improve…
Chemoproteomics has emerged as a key technology as it offers a proteome-wide evaluation of the
selectivity of chemical tools, which offers the advantage of giving insight into and minimising the
risk of…
LCC’s scaffolds are designed to be successfully applied to DNA-compatible reactions. Throughout 2021, we focused our attention on designing novel and diverse DEL scaffolds, particularly Di- and Tri- functionalized…
LCC’s very own Ilaria Proietti Silvestri and Paul Colbon have recently composed a minireview exploring the impact and importance that chirality has in the exploration of 3D chemical space and the specific requirements…
The activation of C-H bonds has rapidly progressed from niche reactions with limited scope to an ever expanding functional toolbox with an increasing number of applications. A key recent development of this field is the activation of …
