of the
Follow our MOtM once a month to see new compounds, recent examples of their applications,
potential breakthroughs, and much more.
LCC’s very own Ilaria Proietti Silvestri and Paul Colbon have recently composed a minireview exploring the impact and importance that chirality has in the exploration of 3D chemical space and the specific requirements…
The activation of C-H bonds has rapidly progressed from niche reactions with limited scope to an ever expanding functional toolbox with an increasing number of applications. A key recent development of this field is the activation of …
Aldehydes are a versatile class and an important building block for DEL design, owing to the numerous amounts of...
Fragment Based Drug Design (FBDD) is a method used in drug discovery which utilises and identifies single or multiple fragment hits to bind ...
LCC have identified an area to support emerging technologies, with the current expanding research into PROTACs and their movement into clinical trials...
Photocatalysis has seen a lot of attention over the past decade which has led to the development of
new...
A recent publication from the Cravatt group is highlighting the importance of enantiomeric probe pairs (also called “enantiopairs”) in the context of small-molecule interactions with proteins in human cells. Numerous stereochemistry-dependent protein-fragment interactions were…
As discussed in our Nov.2020 Molecules of the Month, starting from LCC’s proprietary 3D-rich fragments and working with one of the leaders in the cheminformatics field, the fragments have….
In order to allow researchers to take full advantage of recently published work in the field of DEL (in terms of on-DNA reactions’ development), LCC designed a novel collection of 3D-rich.…
