of the
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potential breakthroughs, and much more.
Constrained γ-amino acids are increasingly employed in drug discovery programmes because of
their desirable properties and lack of representation in the commercial space. LCC has developed synthetic photocatalysis methodologies, to provide access to…
It is important to think outside of the box when trying to innovate within drug discovery – are there ways in which we can improve…
Chemoproteomics has emerged as a key technology as it offers a proteome-wide evaluation of the
selectivity of chemical tools, which offers the advantage of giving insight into and minimising the
risk of…
LCC’s scaffolds are designed to be successfully applied to DNA-compatible reactions. Throughout 2021, we focused our attention on designing novel and diverse DEL scaffolds, particularly Di- and Tri- functionalized…
LCC’s very own Ilaria Proietti Silvestri and Paul Colbon have recently composed a minireview exploring the impact and importance that chirality has in the exploration of 3D chemical space and the specific requirements…
The activation of C-H bonds has rapidly progressed from niche reactions with limited scope to an ever expanding functional toolbox with an increasing number of applications. A key recent development of this field is the activation of …
Aldehydes are a versatile class and an important building block for DEL design, owing to the numerous amounts of...
Fragment Based Drug Design (FBDD) is a method used in drug discovery which utilises and identifies single or multiple fragment hits to bind ...
LCC have identified an area to support emerging technologies, with the current expanding research into PROTACs and their movement into clinical trials...
Photocatalysis has seen a lot of attention over the past decade which has led to the development of
new...
A recent publication from the Cravatt group is highlighting the importance of enantiomeric probe pairs (also called “enantiopairs”) in the context of small-molecule interactions with proteins in human cells. Numerous stereochemistry-dependent protein-fragment interactions were…
