Company Overview

sp3-rich N-heterocycles

Building Blocks
(including scaffolds for DEL synthesis)

Fragments
(3D vector exploration)

Hit-to-lead optimisation
(nearest neighbours for rapid SAR analysis)

Custom synthesis
(FFS or FTE)

Chemistry expertise
(e.g. Asymmetric Hydrogenation and Pd-coupling)

Process development
(for APIs or key intermediates)

Liverpool ChiroChem (LCC) is a chemical technology innovator that produces chiral small molecules for biotech/pharmaceutical R&D. Our specialist products can be used as building blocks, fragments and screening compounds to enable small molecule drug discovery. Our chemical technologies provide efficient access to novel chiral building blocks to allow facile access to new chemical space for hit identification and desirable pharmacokinetic properties for effective lead optimisation. Our proprietary products are ideally suited for DNA-encoded library synthesis and Fragment Based Lead Discovery, which many medicinal chemists consider to be the two leading areas of modern-day drug discovery. 

Locations

United Kingdom

Headquarters and R&D Centre
Liverpool
North West England

China

Analytical Centre & Scale-up Laboratory
Taizhou
Jiangsu

LCC’s core technology:


LCC’s catalytic methods give access to a wide range of chiral amines in excellent enantiomeric purity. Our initial focus is on the production and supply of chiral piperidines and other sp3-rich nitrogen heterocycles , which are of great importance to drug discovery and development due to their excellent pharmacokinetic properties e.g. improved solubility and bioavailability.

LCC's technologies were developed through years of research in the areas of asymmetric hydrogenation and Pd-coupling. LCC now provide collaborate services with our customers to optimise key steps in synthetic routes.


LCC’s core strengths:

  • Production of privileged heterocyclic building blocks using expert synthetic technologies, thus making them readily accessible, chirally pure and available on scale
  • ee data provided for every chiral product
  • Excellent chemical and enantiomeric purity
  • In-depth knowledge of asymmetric hydrogenation and Pd-coupling

Selected Examples of LCC's (a)chiral amines:


Chiral Amines

Established in Liverpool, United Kingdom, June 2014.



Members/Associates of:

Liverpool ChiroChem is part of EnterprisePlus, the Royal Society of Chemistry's service for micro, small and medium-sized companies.